Dennis,
I've found no problem with the Colt Python, stainless or blue.
The barrels and cylinder seem to be a little tougher as in most revolvers.
But no problems to cut, just a little different than the frame.
Again, find some conceled places to make some test cuts if you are in doubt.
Best of luck and enjoy this fine firearm.
You're welcome, Dennis.
I usually test the frame by making a cut on the inside of the side plate.
You can test the cylinder under the star extractor.
The barrel is a little harder to find a hidden place unless it's removed from the frame.
If its removed I test on the lip above the barrel threads.
But if you find the cylinder cut-able the barrel should also be OK.